Peng Lab

Journal Articles (Last Updated 9/6/2022)



Mecca, A. A., Caprara, G. A., & Peng, A. W. (2022). cAMP and voltage modulate rat auditory mechanotransduction by decreasing the stiffness of gating springs. Proceedings of the National Academy of Sciences of the United States of America, 119(30), e2107567119.  CU Anschutz Press Release

Caprara, G. A., & Peng, A. W. (2022). "Mechanotransduction in mammalian sensory hair cells." Molecular and Cellular Neuroscience, 120(September 2021), 103706.



Peng AW, Scharr AL, Caprara GA, Nettles D, Steele CR and Ricci AJ (2021). "Fluid Jet Stimulation of Auditory Hair Bundles Reveal Spatial Non-uniformities and Two Viscoelastic-Like Mechanisms." Front. Cell Dev. Biol. 9:725101.



Caprara, G. A., Mecca, A. A., & Peng, A. W.  "Decades-old model of slow adaptation in sensory hair cells is not supported in mammals." Science Advances, 2020 Aug 14; 6(33), eabb4922.  CU Anschutz Press Release

Li S, Mecca A, Kim J, Caprara GA, Wagner EL, Du TT, Petrov L, Xu W, Cui R, Rebustini IT, Kachar B, Peng AW*, Shin JS*. “Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex.” Nature Communications, 2020 Apr 29; 11(1), 1–15. * Co-corresponding authors  UVA Press Release



Caprara GA, Mecca AA, Wang Y, Ricci AJ, Peng AW. “Hair bundle stimulation mode modifies manifestations of mechanotransduction adaptation.” Journal of Neuroscience, 2019 Oct 2. pii: 1408-19. doi: 10.1523/JNEUROSCI.1408-19.2019



Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. “The tarantula toxin GxTx detains K + channel gating charges in their resting conformation.” Journal of General Physiology, 2019 Mar 4;151(3):292-315. PMC6400525.



Effertz T, Becker L, Peng AW, Ricci AJ. “Phosphoinositol-4,5-bisphosphate regulates auditory hair cell mechanotransduction channel pore properties and fast adaptation.” Journal of Neuroscience, 2017 Oct 24;37(48): 11632-11646. PMC5707765.

Larson T, Doll JC, Loizeau F, Hosseini N, Peng AW, Fantner GE, Ricci AJ, Pruitt BL. Rise time reduction of thermal actuators operated in air and water through optimized pre-shaped open-loop driving. Journal of Micromechanics and Microengineering, 2017 February 24; 27(4): 045005.

Kazmierczak M, Kazmierczak P, Peng AW, Harris SL, Shah P, Puel JL, Lenoir M, Franco SJ, Schwander M. Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner. Journal of Neuroscience, 2017 Feb 16; 37(13): 3447-3464.



Peng AW, Gnanasambandam R, Sachs, F, Ricci AJ. “Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer.” Journal of Neuroscience, 2016 Mar 9; 36(10): 2945–2956.



Nam JH, Peng AW, Ricci AJ. “Underestimated sensitivity of mammalian cochlear hair cells due to splay between stereociliary columns.” Biophysical Journal, 2015 Jun 2; 108(11):2633-47.    PMC4457497.



Peng AW, Effertz T, Ricci AJ. “Adaptation of Mammalian Auditory Hair Cell Mechanotransduction Is Independent of Calcium Entry.” Neuron, 2013 Nov 20; 80(4):960-972. PMC4111567. Stanford Press Release



Doll JC, Peng AW, Ricci AJ, Pruitt BL. “Faster Than the Speed of Hearing: Nanomechanical Force Probes Enable the Electromechanical Observation of Cochlear Hair Cells.” Nano Letters, 2012 Dec 12; 12(12): 6107–6111. PMC3549426.

Castallano-Munoz M, Peng AW, Salles FT, Ricci AJ. “Swept field laser confocal microscopy for enhanced spatial and temporal resolution in live-cell imaging.” Microscopy and Microanalysis, 2012 Aug;18(4):753-60. PMC3549604.



Peng AW, Salles FT, Pan B, Ricci AJ. “Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction.” Nature Communications, 2011 Nov 1; 2:523. PMC3418221.

Peng AW, Ricci AJ. “Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?” Hearing Research, 2011 Mar; 273:109-22. PMC2943979.



Oshima K, Shin K, Diensthuber M, Peng AW, Ricci AJ, Heller S. “Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells.” Cell, 2010 May 14; 141:704-16. PMC2873974.



Peng AW, Belyantseva IA, Hsu PD, Friedman TB, Heller S. “Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.” Journal of Neuroscience. 2009 Dec 2; 29(48): 15083-88. PMC2823077.



Xu Z, Peng AW, Oshima K, Heller S. “MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23.” Journal of Neuroscience. 2008 Oct 29;28(44):11269-76. PMC2596868.



Book Chapters



Peng AW, Ricci AJ. Glass Probe Stimulation of Hair Cell Stereocilia. In: Sokolowski B, editor. Auditory and Vestibular Research: Methods and Protocols. Second Edition. Springer New York; 2016. p. 487–500.